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News & Events > Mount Sinai researchers identify key gene driver of Fibromuscular Dysplasia offering new hope for treatment

Mount Sinai researchers identify key gene driver of Fibromuscular Dysplasia offering new hope for treatment

BREAKING NEWS!

Mount Sinai researchers identify key gene driver of Fibromuscular Dysplasia offering new hope for treatment

“In a study published September 13 in Nature Cardiovascular Research, the team said changes in the gene UBR4 played an important role as a key driver of FMD. They suggested the discovery could be an important step toward developing a therapeutic approach for the disorder.

By identifying a gene and its gene regulatory network that appear to account for a significant portion of FMD heritability, scientists believe they have taken a major step toward a therapeutic solution. “Our study opens the door to targeted modulation of UBR4 and its disease-relevant gene regulatory network, and that could hold tremendous promise for the many people, particularly women, with this condition,” emphasizes Dr. Kovacic.”

To read the full Mount Sinai Press Release:
https://www.mountsinai.org/about/newsroom/2024/scientists-discover-potential-cause-of-an-enigmatic-vascular-disease-primarily-impacting-women

Victor Chang Press Release:
https://www.victorchang.edu.au/news/cause-fmd-research

Nature Article Abstract:
https://www.nature.com/articles/s44161-024-00533-w

Dr Kovacic has agreed to participate in a Zoom to discuss the study findings, we will share more details on our social media once they are confirmed.

We are so grateful to everyone involved in this study and publication.

Thank you to Dr Olin and Dr Kovacic, their teams, all the researchers who have worked on this study and paper and finally to all those who participated in this study as a patient or control by donating their skin samples. This is an exciting development!

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